What is Albuterol Made Of?
Albuterol, also known as salbutamol, is a bronchodilator that helps relax the muscles in the airways, making it easier to breathe. The active ingredient in albuterol is albuterol sulfate, a synthetic beta2-adrenergic agonist. In addition to the active ingredient, albuterol inhalers typically contain several inactive ingredients, such as propellants (like hydrofluoroalkane), preservatives (like benzalkonium chloride), and buffering agents (like sodium chloride and sulfuric acid) to help stabilize the formulation and maintain the proper pH balance.
Albuterol, a well-known bronchodilator, has been a staple in asthma treatment for decades. With its active ingredient, albuterol sulfate, and various inactive components, this medication provides rapid relief from bronchospasm and improves lung function. Developed in the 1960s and now prescribed worldwide, albuterol is a proven and effective treatment option for people with asthma and other respiratory conditions.
What does each ingredient in Albuterol do?
- Albuterol sulfate: This is the active ingredient that works by stimulating beta2-adrenergic receptors in the smooth muscles of the bronchial tubes, causing them to relax and widen, allowing more air to flow through.
- Propellant (hydrofluoroalkane): This substance is used to propel the medication out of the inhaler, allowing it to be inhaled into the lungs.
- Benzalkonium chloride: This is a preservative that helps prevent contamination of the inhaler and keeps the medication stable.
- Sodium chloride and sulfuric acid: These buffering agents help maintain the proper pH balance within the inhaler, ensuring the medication remains effective.
| Albuterol Ingredient | Function |
| Albuterol sulfate | Active ingredient; bronchodilator that helps relax airway muscles and improve breathing |
| Inactive Albuterol ingredients (examples) | |
| Lactose | Filler and stabilizer for the medication formulation |
| Magnesium stearate | Lubricant to prevent ingredients from sticking to manufacturing equipment |
| Microcrystalline cellulose | Filler and binder to provide structure and stability to the tablet |
| Sodium chloride | Isotonic agent; helps balance the solution in liquid formulations |
| Purified water | Solvent for liquid formulations |
| Oleic acid | Stabilizer and surfactant in aerosol formulations |
| Hydrofluoroalkane (HFA) propellant | Propellant used in aerosol formulations to deliver the medication |
When Was Albuterol Developed?
Albuterol was first developed in the 1960s as a short-acting bronchodilator for the treatment of asthma and other respiratory conditions. It was initially marketed as Ventolin, and over time, it became one of the most widely prescribed medications for asthma worldwide.
What Do Studies Show About Albuterol’s Effectiveness?
Numerous studies have demonstrated the effectiveness of albuterol in providing rapid relief from bronchospasm and improving lung function in patients with asthma and other obstructive pulmonary diseases. Albuterol is considered a first-line treatment for acute asthma exacerbations and is also used as a maintenance therapy for long-term asthma management.
What are Albuterol’s Side Effects?
Albuterol is generally well-tolerated, but like any medication, it can cause side effects. Some of the most common side effects include:
- Tremors
- Headaches
- Rapid or irregular heartbeat
- Nervousness
- Dizziness
- Sore throat
- Muscle cramps
Article Highlights
- Albuterol is a bronchodilator made up of albuterol sulfate and several inactive ingredients, such as propellants, preservatives, and buffering agents.
- Albuterol sulfate is the active ingredient that works by stimulating beta2-adrenergic receptors, causing airway muscles to relax.
- Developed in the 1960s, albuterol is now a widely prescribed medication for asthma and other respiratory conditions.
- Studies show that albuterol is effective in providing rapid relief from bronchospasm and improving lung function.
- Common side effects of albuterol include tremors, headaches, and rapid heartbeat, but more serious side effects are rare.
Citations:
- Global Initiative for Asthma (GINA). (2021). Global Strategy for Asthma Management and Prevention. Retrieved from https://ginasthma.org/wp-content/uploads/2021/05/GINA-Main-Report-2021-V2-WMS.pdf
- National Asthma Education and Prevention Program. (2007). Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Retrieved from https://www.nhlbi.nih.gov/files/docs/guidelines/asthgdln.pdf
- Volmer T, Effenberger T, Trautner C, Buhl R. (2008). Consequences of long-term oral administration of the ß2-adrenoceptor agonist clenbuterol on the ß1- and ß2-adrenoceptor subtypes in the human heart. Journal of Cardiovascular Pharmacology. 51(1): 94-100.
- Cazzola M, Matera MG. (2010). Novel bronchodilators in asthma. Current Opinion in Pulmonary Medicine. 16(1): 6-12.
- Nelson HS. (2003). ß-agonists: what is the evidence that their use increases the risk of asthma morbidity and mortality? Journal of Allergy and Clinical Immunology. 112(3 Suppl): S18-26.
- Salpeter SR, Ormiston TM, Salpeter EE. (2004). Meta-analysis: respiratory tolerance to regular ß2-agonist use in patients with asthma. Annals of Internal Medicine. 140(10): 802-813.
- Dekhuijzen R, Bjermer L. (2000). Local and systemic side effects of inhaled corticosteroids: current concepts and future strategies. European Respiratory Journal. 14(1): 196-209.
